L’infirmière en chef Ratched règne en maître sur son service. Jusqu’au jour où débarque McMurphy, un sacré énergumène bien décidé à redistribuer les cartes et à redonner un peu de dignité et d’espoir aux malades. Rebelle et gouailleur, il engage alors à ses risques et périls une résistance acharnée contre l’institution.
Tyrannical Nurse Ratched rules her ward in an Oregon State mental hospital with a strict and unbending routine, unopposed by her patients, who remain cowed by mind-numbing medication and the threat of electroshock therapy. But her regime is disrupted by the arrival of McMurphy - the swaggering, fun-loving trickster with a devilish grin who resolves to oppose her rules on behalf of his fellow inmates. His struggle is seen through the eyes of Chief Bromden, a seemingly mute half-Indian patient who understands McMurphy's heroic attempt to do battle with the powers that keep them imprisoned. The subject of an Oscar-winning film starring Jack Nicholson, One Flew Over the Cuckoo's Nest an exuberant, ribald and devastatingly honest portrayal of the boundaries between sanity and madness.